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Binding Proteins Proteins that bind to water-soluble hormones, such as sex hormones, cortisol, and thyroid; or certain water-soluble proteins, such as insulin-like growth factor to maintain stable circulating levels of the hormone in the bloodstream.   Biological Marker of Aging Any physiological marker that appears to be universal in an aging population.   Biological Response Modifier Any molecule that can modify the biological response of cells to changes in its external environment.   Blood Glucose The primary source of energy for the brain. Elevated blood glucose levels cause diabetes and accelerate aging.