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The Problem Cardiovascular disease is caused by chronic low-level inflammation (1, 2). The ultimate cause is a pro-inflammatory diet. The consequences of such a pro-inflammatory diet leads to the build-up of atherosclerotic lesions, the rupture of those lesions, and an inability to repair damaged tissue to maintain an efficient cardiovascular system.
The Traditional Medical Approach Drugs (such as statins) that lower cholesterol are the primary drugs currently used to treat heart disease. Statins are known to activate AMPK, which also inhibits cholesterol synthesis (3,4). Thus, statins could be considered to be AMPK-activating drugs. Cardiovascular disease is also correlated with increased oxidative stress (5). Finally, cardiovascular disease is highly associated with insulin resistance (6).
The Metabolic Engineering® Approach The molecular drivers of cardiovascular disease can be attenuated by consistent use of Metabolic Engineering®. The Zone diet component activates AMPK due to calorie restriction (7). The omega-3 fatty acid component reduces inflammation and increases its resolution (8). Finally, the polyphenols reduce oxidative stress (5).
Thus, Metabolic Engineering® works in concert with any drug therapy for cardiovascular treatment to help reprogram your metabolism by activating AMPK. Activation of AMPK decreases cholesterol synthesis, reduces inflammation, increases resolution, and decreases oxidative stress by increasing Nrf2 activity. The overall effect is a decrease in insulin resistance as well as the level of cellular senescence. These benefits of Metabolic Engineering® either make a cardiovascular drug work better or allow the physician to potentially reduce the amount of drug to manage their patient’s cardiovascular disorder with fewer side effects.
References 1. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002; 105(9):1135-43. doi: 10.1161/hc0902.104353.