Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.
How we can help you:
At vero eos et accusamus et iusto odio dignissimos ducimus qui blanditiis praesentium voluptatum deleniti atque corrupti quos dolores et quas.
Itaque earum rerum hic tenetur a sapiente delectus, ut aut reiciendis voluptatibus maiores alias consequatur aut perferendis doloribus asperiores repellat.
The Problem Obesity has become a worldwide epidemic. Excess body fat is usually the first physical sign that your metabolism is disrupted and that your level of insulin resistance is rising, however, about 16 percent of normal weight individuals have severe insulin resistance (1). Not only is obesity a chronic inflammatory condition, but it also increases the production of senescent cells that drive the aging process (2).
The physiological foundation of obesity is insulin resistance caused by decreased AMPK activity (3,4). If AMPK activity is inhibited, the burning of excess body fat in every organ is compromised, and fat stores continue to increase. However, that same inhibition of AMPK activity will also have negative consequences on your immune system, the ability to resolve inflammation, the expression of your genes, and the acceleration of aging.
The Traditional Medical Approach The search for weight loss drugs has continued for nearly a century and has yet to generate sustainable results. The current generation of injectable weight loss drugs stops hunger and reduces calorie intake, thus leading to weight loss. Unfortunately, much of that weight loss comes from losing lean body mass (5). This loss of lean body mass reduces the metabolic efficacy of every organ in the body.
The Metabolic Engineering® Approach Metabolic Engineering® is a more comprehensive dietary technology that improves metabolic efficiency and repairs damaged tissue by activating AMPK (6). Increased AMPK activity also stimulates the oxidation of stored fat in every cell in the body.
The goal of Metabolic Engineering® is to activate AMPK in the adipose tissue. Using the Zone diet component of Metabolic Engineering® to restrict calories without hunger or fatigue is the most powerful dietary approach for increasing AMPK activity. The omega-3 fatty acid dietary component of Metabolic Engineering® reduces neuroinflammation and promotes its resolution. The polyphenol dietary component of Metabolic Engineering® reduces oxidative stress. Equally important is that the omega-3 fatty acid and polyphenol components of Metabolic Engineering® are also indirect activators of AMPK activity. Thus, combining all three dietary interventions in Metabolic Engineering® provides the optimal dietary approach to maximizing AMPK activity to metabolize stored excess body fat for energy.
An added benefit of following Metabolic Engineering® to reduce excess body fat is that it also reduces cellular senescence (7). Fat loss leads to a longer healthspan, which is the true benefit.
5. Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group.Once-weekly semaglutide in adults with overweight or obesity. N Engl J Med. 2021; 384: 989-1002. doi: 10.1056/NEJMoa2032183.