Chronic Diseases

Many common chronic disease conditions are strongly associated with increased insulin resistance. This is because insulin resistance is a surrogate marker for an inefficient metabolism, leading to increased chronic low-level inflammation and a growing population of senescent cells that accelerate aging throughout the body. The biological consequences of increased insulin resistance can be attenuated, if not reversed, by Metabolic Engineering®.

Metabolic Engineering® is a defined dietary program to reduce insulin resistance and its associated chronic low-level inflammation that increases cellular senescence. At the molecular level, Metabolic Engineering® activates the master switch of metabolism, AMPK. The power of Metabolic Engineering® is the ability to keep AMPK within a zone in each of your 30 trillion cells. The result is an increased healthspan, defined as longevity minus years of disability caused by chronic disease.

There is no magic bullet (drug or supplement) to achieve this dynamic metabolic balance of AMPK in every cell. However, there is a synergistic balance of three unique interrelated dietary strategies that can.

The first strategy is calorie restriction but without hunger or fatigue. This is only feasible if the calorie restriction is accomplished without hunger or fatigue. The Zone diet is a patented technology that achieves this goal by balancing protein-to-glycemic load. The Zone diet is the foundation for Metabolic Engineering® as it is the most potent dietary approach to activate AMPK that no current drug or supplement can match. The second dietary strategy you also need is the adequate intake of omega-3 fatty acids to provide the building blocks for a powerful group of hormones (i.e., resolvins) that turn off chronic low-level inflammation that drives all chronic diseases. It is difficult to achieve adequate intake of omega-3 fatty acids by diet alone, so supplementation is often needed. Finally, the third dietary strategy is the requirement for an adequate intake of polyphenols. These are chemicals that give vegetables and fruits their color. They are also critical to the repair of damaged tissue caused by insulin resistance. Like omega-3 fatty acids, it is often difficult to consume adequate intake of polyphenols, so supplementation is also usually required. In addition, omega-3 fatty acids and polyphenols indirectly activate AMPK. Thus, all dietary components work together as an integrated team to keep AMPK in the appropriate zone to extend healthspan.Equally important, Metabolic Engineering® can be personalized to the individual based on blood testing to determine the correct balance of its three dietary components to generate optimal results in reducing insulin resistance. The more consistently you follow the dietary guidelines of Metabolic Engineering®, the more likely you will reduce the underlying cause of most chronic health conditions, which is the growing population of senescent cells associated with increasing levels of insulin resistance.

The ultimate goal of Metabolic Engineering® is to reduce the number of senescent cells throughout the body to slow down your rate of aging. Thus, the real benefit of Metabolic Engineering® is an increased healthspan. This should be the primary goal of medicine instead of using more drugs to treat the symptoms of chronic disease.

The various chronic disease conditions that can benefit from consistent use of Metabolic Engineering® are shown below.

Asthma

Auto-immune diseases

Cancer

Cardiovascular disease

Infertility