The most effective way to activate AMPK is by calorie restriction.  Once AMPK is activated, you burn fat faster, improve metabolic efficiency, and slow down aging. 

The secret is doing it for a lifetime.   GLP-1 drugs cause calorie restriction by using excessive levels of injectable hormones to suppress appetite control center in the brain.   

ZoneRx Foods activate the same appetite control centers in the brain using the natural pathway from the gut to the brain via the vagal nerve. Same result, but without the side effects of GLP-1 drugs.