Insulin resistance is a key factor in many health issues, and measuring it doesn’t always require expensive tests. The triglyceride (TG) to high-density lipoprotein cholesterol (HDL) ratio, commonly included in routine blood work, serves as a reliable surrogate marker. Insulin resistance is often linked to increased body fat, with its earliest effects showing in the liver, where dietary fats are repackaged into lipoproteins. As insulin resistance develops, triglyceride levels rise, HDL decreases, and LDL particles become smaller and denser.
Topics discussed:
00:00 How do you define Wellness?
01:12 Understanding the HOMA-IR blood test
02:36 What causes insulin Resistance is inflammation
03:42 Chronic diseases caused by insulin resistance
04:38 Why Americans don’t consume enough protein, or eat the right balance of carbs and fats.
05:08 Metabolic Engineering and treating food like a drug
06:45 Managing diet, exercise, and stress reduction—the 80-15-5 rule

1 comment
I come from China and I am a loyal reader and user of Dr. Sears and the Zone Diet . There are two issues that have been bothering me all along and I hope Dr. Sears can provide answers to them:
1. I have planned out the total block of food portions for the whole day and have also planned three main meals and two snacks. However, due to work or other reasons, there will be one meal that is seriously over-consumed. In such a situation, should I continue to eat according to the original plan and consume the remaining meals within the planned portion numbers? Or should I turn them all into snacks (one block)? If I do so, considering the absorption rate of protein in the body for a single (over-consumed) intake, will it affect the protein deficiency?
2. Zone Diet Theory mentions that before, during, and after exercise, one should consume regional snacks. Should I eat one block for the three occasions? (Then, do these three block still count towards the total block of portions needed for the whole day?) Or should I split one snack into three portions and eat them separately?