Live Longer. Live Better.
This is Life In The Zone.
The Zone is a clinically defined state in which your metabolism
is working at peak efficiency. The only way to reach the
Zone is by following Metabolic Engineering®.
What Metabolic Engineering?
Metabolic Engineering®, is the three-part dietary system designed to help you reach and maintain the Zone. Developed by Dr. Barry Sears, it focuses on improving metabolic efficiency by activating AMPK, the body’s master regulator of metabolism.
Benefits of Being in the Zone
A clinically guided approach to optimize metabolic health and everyday performance.
click below to learn more.
The Pathway to the Zone is through Metabolic Engineering
Developed by Dr.Barry Sears, Metabolic Engineering® is an evidence-based dietary system. It consists of the Zone diet, omega-3 fatty acids, and polyphenols to reprogram the genes that control your metabolism.
- The Zone diet activates AMPK, the master regulator of metabolism.
- Omega-3 fatty acids reduce and resolve inflammation that disrupts metabolism.
- Polyphenols reduce oxidative stress that damages DNA and accelerates aging.
A Free, In-Depth Guide To Metabolic Engineering® by Dr. Sears
Plus, continuous science-based focused content
Want to Learn More?
Click below to visit out Metabolic Engineering, where we break it down for you. Visit to also get our detailed guidebook.
Zone living Products
There is only one way to reach the Zone. Follow the three part system called Metabolic Engineering.
Zone univeristy
A regularly updated library of Dr. Barry Sears’ research — featuring podcasts, articles, and blogs that deliver science-backed insights and practical guidance to optimize your metabolism.
Join Our Community
Reaching the Zone using Metabolic Engineering® requires knowledge. Join our community to get weekly insights into how Metabolic Engineering® can improve your current state of wellness. It’s never too late to start.
About Dr. Barry Sears
Dr. Barry Sears is a leading authority on the hormonal impact of food and the creator of the Zone Diet, the nutritional framework that redefined how the world thinks about the relationship between diet, inflammation, and wellness. His 1995 book The Zone became a #1 New York Times bestseller and launched a global movement, with more than 6 million copies of his books sold across 40 languages. Over three decades later, the principles he introduced remain the foundation of modern metabolic health.
Trust & Credibility
What leading medical researchers say about metabolic engineering:
Dr. Sear’s vision is clearly presented continually building fundamental new discoveries from experimental medicine.
Dr. Charles Serhan
Director of the Center for Experimental Therapeutics at Harvard Medical School
Dr. Sears’ decades of research to understand the role of diet in controlling inflammation and the resulting disease conditions it causes is compelling.
Dr Sear’s books
The history of the Zone Through Dr. Sear’s Best-Selling Books
The Omega Rx Zone:
The Miracle of the New High-Dose Fish Oil
The Omega Rx Zone is Dr. Barry Sears’s influential Zone-series book on the power of high-dose, pharmaceutical-grade fish oil to transform health and chronic disease. Part of Sears’s groundbreaking work on diet and inflammation, the book expands the Zone principles with research showing how concentrated omega-3s support brain function, hormonal balance, performance, and disease prevention.
Trust & Credibility
What leading medical researchers say about Metabolic Engineering®
Bringing Metabolic Science to the World
Sharing evidence-based insights on nutrition, longevity, and metabolic health—around the globe.
Stanford University
The Future of Metabolic Health & Longevity
Dr. Sears explores how metabolic engineering, nutrition science, and lifestyle medicine intersect to support long-term health and disease prevention.
March 12, 2026 | 4:00 PM PST
Stanford, CA
Harvard Medical School
Nutrition Science in Clinical Practice
A deep dive into translating nutritional research into real-world clinical outcomes, with a focus on inflammation, insulin sensitivity, and patient care.
April 5, 2026 | 6:30 PM EST
Boston, MA
University of California
Metabolic Engineering & Human Performance
An engaging session on optimizing metabolic pathways to improve cognitive performance, energy, and long-term vitality.