Live Longer. Live Better.
This is Life In The Zone.
The Zone is a clinically defined state in which your metabolism
is working at peak efficiency. The only way to reach the
Zone is by following Metabolic Engineering®.
Benefits of Being in the Zone
A clinically guided approach to optimize metabolic health and everyday performance.
What
Metabolic
Engineering?
There is no magic bullet for living longer and better. But there is a system. It’s called Metabolic Engineering® and it consists of three integrated dietary steps that will get you to the Zone. It’s not a linear process, it’s a holistic way of living.
The Pathway to the Zone is through Metabolic Engineering
Developed by Dr.Barry Sears, Metabolic Engineering® is an evidence-based dietary system. It consists of the Zone diet, omega-3 fatty acids, and polyphenols to reprogram the genes that control your metabolism.
- The Zone diet activates AMPK, the master regulator of metabolism.
- Omega-3 fatty acids reduce and resolve inflammation that disrupts metabolism.
- Polyphenols reduce oxidative stress that damages DNA and accelerates aging.
A Free, In-Depth Guide To Metabolic Engineering® by Dr. Sears
Plus, continuous science-based focused content
Want to Learn More?
Click below to visit out Metabolic Engineering, where we break it down for you. Visit to also get our detailed guidebook.
Zone living Products
There is only one way to reach the Zone. Follow the three part system called Metabolic Engineering.
Zone univeristy
A complete library of Dr. Barry Sears’ research — featuring podcasts, articles, and blogs that deliver science-backed insights and practical guidance to optimize your metabolism.
Key Takeaways Diet definitions are confusing because most diets are defined by philosophy rather than science. A clearer way to define a diet is by three measurable factors: its macronutrient
Key Takeaways Yes—the Zone Diet may still be ahead of its time. Unlike most diet trends that focus on eliminating a single nutrient, the Zone Diet was designed to control
Key Takeaways GLP-1 drugs restrict calorie intake, leading to rapid metabolic benefits. So does Metabolic Engineering®. The critical question is whether those benefits can be sustained long-term without continuous reliance
Key Takeaways Metabolism is incredibly complex. It is dynamic and governed by a highly sophisticated series of interlocking feedback mechanisms to keep it in a zone of optimal efficiency. Yet
Key Takeaways Diet definitions are confusing because most diets are defined by philosophy rather than science. A clearer way to define a diet is by three measurable factors: its macronutrient
Key Takeaways Yes—the Zone Diet may still be ahead of its time. Unlike most diet trends that focus on eliminating a single nutrient, the Zone Diet was designed to control
Trust & Credibility
What leading medical researchers say about metabolic engineering:
Dr. Sear’s vision is clearly presented continually building n fundamental new discoveries from experimental medicine.
Dr. Charles Serhan
Director of the Center for Experimental Therapeutics at Harvard Medical School
Dr. Sears’ decades of research to understand the role of diet in controlling inflammation and the resulting disease conditions it causes is compelling.
Dr Sear’s books
The history of the Zone Through Dr. Sear’s Best-Selling Books
The Omega Rx Zone:
The Miracle of the New High-Dose Fish Oil
The Omega Rx Zone is Dr. Barry Sears’s influential Zone-series book on the power of high-dose, pharmaceutical-grade fish oil to transform health and chronic disease. Part of Sears’s groundbreaking work on diet and inflammation, the book expands the Zone principles with research showing how concentrated omega-3s support brain function, hormonal balance, performance, and disease prevention.
Trust & Credibility
What leading medical researchers say about Metabolic Engineering®
Bringing Metabolic Science to the World
Sharing evidence-based insights on nutrition, longevity, and metabolic health—around the globe.
Stanford University
The Future of Metabolic Health & Longevity
Dr. Sears explores how metabolic engineering, nutrition science, and lifestyle medicine intersect to support long-term health and disease prevention.
March 12, 2026 | 4:00 PM PST
Stanford, CA
Harvard Medical School
Nutrition Science in Clinical Practice
A deep dive into translating nutritional research into real-world clinical outcomes, with a focus on inflammation, insulin sensitivity, and patient care.
April 5, 2026 | 6:30 PM EST
Boston, MA
University of California
Metabolic Engineering & Human Performance
An engaging session on optimizing metabolic pathways to improve cognitive performance, energy, and long-term vitality.
May 18, 2026 | 5:00 PM PST
San Diego, CA
About Dr. Barry Sears
Dr. Barry Sears is considered the founder of Metabolic Engineering based on his ground-breaking research on the dietary manipulation of the hormones that control the initiation and resolution of inflammation.
Dr. Sears’ early research had little to do with nutrition. He was the founder of one of the first biotechnology companies in Massachusetts in the 1970s, specializing in developing intravenous lipid-based cancer drug delivery systems. His patents issued in the early 1980s for inventing unique lipids (i.e., PEG-linked phospholipids) led to the first nanotechnology cancer drug that is still used today. The same lipids are used today in various mRNA vaccines for treating Covid-19.
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