Polycystic Ovary Syndrome (PCOS)

The Problem
The most common condition associated with female infertility is polycystic ovarian syndrome (PCOS).  PCOS is also strongly associated with increased insulin resistance (1,2).  

The Traditional Medical Approach
There is no cure for PCOS.  Thus, the best approach is the dietary reduction of insulin resistance.

The Metabolic Engineering® Approach
The best strategy is to reduce insulin resistance by activating AMPK (3).  Metabolic Engineering® is a proven dietary technology to reduce existing insulin resistance.  Using the Zone diet component of Metabolic Engineering® to restrict calories without hunger or fatigue is the most powerful dietary approach for lowering insulin resistance because of its direct impact on increasing AMPK activity.  The omega-3 fatty acid and polyphenol components of Metabolic Engineering® are indirect activators of AMPK activity. Thus, combining all three dietary interventions in Metabolic Engineering® provides the optimal approach to maximizing AMPK activity to reduce insulin resistance.

References
1. Zhao, H., Zhang, J., Cheng, X. et al.  Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment. J Ovarian Res. 2023; 16:9. org/10.1186/s13048-022-01091-0

2. Li M, Chi X, Wang Y, Setrerrahmane S, Xie W, Xu H.  Trends in insulin resistance: Insights into mechanisms and therapeutic strategy.  Signal Transduct Target Ther. 2022; 7:216. doi: 10.1038/s41392-022-01073-0.

3. Sears B, Saha AK.  Dietary control of inflammation and resolution.Front Nutr. 2021; 8:709435. doi: 10.3389/fnut.2021.709435.