Health Consequences of a Blocked Resolution Response

Health Consequences of the Blocked Resolution Response
The reason you want to maintain an optimal Resolution Response is because of the acceleration of the development of chronic disease and aging if you don’t.  But the underlying reason is why?  The simple answer is unresolved cellular inflammation caused by an injury.

The definition of any injury that causes inflammation is quite broad.  This would include microbial threats such as viruses, bacteria, fungi, and parasites, external threats as UV or ionizing radiation, as well as internal injuries caused by accidents.  It would also include internal injuries caused by normal functioning such as turbulent blood flow in the branch points of an artery, oxidative stress, inflammatory responses to damaged cellular components, or breaches of the various (gut, vascular, and blood-brain) barriers within the body allowing entry of microbial or metabolic components into otherwise privileged locations in the body that will cause an inflammatory response.  There are also a large number of prescription drugs that also cause inflammation by either inhibition of mitochondrial function or by inducing cellular senescence.  Finally, the definition of injury can also include various stressors such as exercise-induced injuries, psychological stress, and exposure to environmental toxins.  All of these diverse injuries will ultimately induce an inflammatory response.

The second phase of inflammation that is only activated after the initiation of inflammation caused by an injury.  This is the Resolution Response that results in the healing of the tissue damage caused by any potential inflammation-inducing injury and thus allows the organ to return to homeostasis.  Unfortunately, without an optimal Resolution Resolution the inflammation induced by the initial injury can linger in the body even through the original cause of the injury may no longer exist in the body.   

There are two pathways that bridge the gulf between unresolved cellular inflammation and the development of chronic disease.  One is development of cellular senescence and the other the development of fibrosis or scar tissue.

Cellular Senescence
Inflammatory damage to any cell cause can potentially cause cellular senescence.  The cell no longer replicates, but is transformed to become a generator of continuing inflammation.  These are equivalent to zombie cells.  Furthermore, the constant flow of inflammatory mediators from these zombie cells can induce cellular senescence in neighboring cells.

An optimal Resolution Response can activate the immune system to destroy such cells, but a blocked Resolution Response will prevent that from happening.  As a result, zombie cell population in that organ continues to exist, expand, and keep the inflammation going.

The types of chronic diseases associated with cellular senescence include obesity, diabetes, heart disease, auto-immune diseeses, Alzhemier’s, and the acceleration of aging often called inflammaging.

Even more ominous than cellular senescence is the development of fibrosis or scar tissue formation.  This occurs when the site of unresolved inflammation is encased in scar tissue to prevent any  further inflammatory damage to the organ.  The function of that part of the organ is lost and with enough scar tissue formation in the organ, it ceases to function completely.   About 45 percent of all mortality  is associated with extensive scar tissue formation.

The most effective way to treat these conditions is to go the core of the problem which is to optimize the Resolution Response

The types of diseases associated with fibrosis are lung disease, liver disease, kidney disease, heart disease, and heart failure.