Live Longer. Live Better.
This is Life In The Zone.
The Zone is a clinically defined state in which your metabolism
is working at peak efficiency. The only way to reach the
Zone is by following Metabolic Engineering®.
Benefits of Being in the Zone
A clinically guided approach to optimize metabolic health and everyday performance.
The Pathway to the Zone is through Metabolic Engineering
Developed by Dr.Barry Sears, Metabolic Engineering® is an evidence-based dietary system. It consists of the Zone diet, omega-3 fatty acids, and polyphenols to reprogram the genes that control your metabolism.
- The Zone diet activates AMPK, the master regulator of metabolism.
- Omega-3 fatty acids reduce and resolve inflammation that disrupts metabolism.
- Polyphenols reduce oxidative stress that damages DNA and accelerates aging.
A Free, In-Depth Guide To Metabolic Engineering® by Dr. Sears
Plus, continuous science-based focused content
Products designed by Dr. Sears to support Metabolic Engineering® at zoneliving.com
ZoneRx Foods
Activates AMPK
OmegaRx
Reduce Inflammation
PolyphenolsRx
Reduce DNA Damage
Zone Education
Ask Dr. Sears
Separating truth from fiction in nutritional science
The Wellness Zone Podcast
(with Mary Perry, Zone Labs Clinical Trials Director): In-depth conversations on the science of wellness.
Zone Science
Breaking news in research relevant to the Zone
- Zone Science: Breaking news in research relevant to the Zone
- Ask Dr. Sears: Separating truth from fiction in nutritional science
- The Wellness Zone Podcast (with Mary Perry, Zone Labs Clinical Trials Director): In-depth conversations on the science of wellness.
Choose your area of interest.
How Long Can a Person Fast?
The human body is very fragile. You can go without breathing for about three minutes. You can go without water for about three days. Beyond
NY Times on Sugar: Here’s What They Missed
Last year, the NY Times had an article entitled This Is Your Body on Sugar (1). I thought this might be a good time
Ask Dr. Sears: Everything You Wanted to Know About HbA1c (But Didn’t Want to Google)
A major women’s magazine recently asked me some questions on HbA1c. Here are my answers: Why is HbA1C an important metric for blood sugar control?
Not Just Protein: The Critical Role of Fiber in Fat Loss
Protein gets all the hype—but are you overlooking the real secret to weight loss? In this video, Dr. Barry Sears breaks down the powerful combination
How Much Protein Should You Eat to Lose Weight?
When it comes to weight loss, most people are asking the wrong question. It’s not “How much protein do I need to lose weight?” —
Can Alcohol Cause Panic Attacks?
If you’re prone to anxiety, the answer might surprise you. In this video, Dr. Barry Sears explains the science behind how alcohol interacts with your
Explore Chronic Conditions That Can Be Improved by Metabolic Engineering®
Obesity
Type 2 Diabetes
Cardiovascular
Auto-Immune
Neurological
Fertility
Liver/Kidney
Others
Obesity
Type 2 Diabetes
Cardiovascular
Auto-Immune
Neurological
Fertility
Liver/Kidney
Others
Trust & Credibility
What leading medical researchers say about Metabolic Engineering®
Bringing Metabolic Science to the World
Sharing evidence-based insights on nutrition, longevity, and metabolic health—around the globe.
Stanford University
The Future of Metabolic Health & Longevity
Dr. Sears explores how metabolic engineering, nutrition science, and lifestyle medicine intersect to support long-term health and disease prevention.
March 12, 2026 • 4:00 PM PST
Stanford, CA
Harvard Medical School
Nutrition Science in Clinical Practice
A deep dive into translating nutritional research into real-world clinical outcomes, with a focus on inflammation, insulin sensitivity, and patient care.
April 5, 2026 • 6:30 PM EST
Boston, MA
University of California
Metabolic Engineering & Human Performance
An engaging session on optimizing metabolic pathways to improve cognitive performance, energy, and long-term vitality.
May 18, 2026 • 5:00 PM PST
San Diego, CA
About Dr. Barry Sears
The concept of the Zone was developed over the past 30 years by Dr. Barry Sears to understand how diet impacts the expression of our genes and controls metabolism. Dr. Sears is an internationally recognized medical researcher and inventor, holding major patents in the areas of cancer drug delivery systems and insulin resistance reduction. It is this dual background of basic research, coupled with the development of groundbreaking inventions, that has allowed Dr. Sears to create innovative food products that can reprogram human metabolism.
Dr. Barry Sears
Medical Researcher – Inventor
Join Our Zone Community
Sign up for research updates, articles, and podcast releases from Dr.Sears .