AMPK and Infertility: The Metabolic Key to Getting Pregant

AMPK and Infertility: The Metabolic Key to Getting Pregant

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Posted: October 15, 2024 

Watch Time: 45 minutes

Posted: April 25, 2025

Watch Time: 05:58 minutes

Hosted By:

Dr. Barry Sears

By Dr. Barry Sears

Founder & President, Zone Labs

Mary Perry

Mary Perry

Clinical Trials Director, Zone Labs

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Summary

Infertility is deeply personal—and increasingly common. In this episode of The Wellness Zone podcast, Dr. Barry Sears and Mary Perry explore the surprising connection between infertility and your metabolism.

What’s behind the rising rates of infertility in both women and men? According to Dr. Sears, it comes down to one key metabolic regulator: AMPK. From polycystic ovary syndrome (PCOS) to declining sperm count and motility, many root causes of infertility are tied to insulin resistance and low AMPK activity.

Dr. Sears explains:

Why obesity and insulin resistance impair fertility

How low AMPK affects sperm movement and egg viability

The role of metformin—and what it teaches us about boosting AMPK naturally

Why conception is a “metabolic symphony,” and what happens when it’s out of tune

If you’re struggling with infertility or simply curious about the science behind reproductive health, this episode provides a powerful and hopeful perspective grounded in the latest metabolic research.

Topics We Discuss:

[00:00]- Intro

[00:55]- Causes of Infertility. Body Fat makes it harder

[01:05]- Making ATP

[01:50]- Male Infertility and AMPK

[03:22]- Metformin and raising AMPK levels

[04:15]- Preparing to conceive by focusing on metabolism

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