AMPK and Infertility: The Metabolic Key to Getting Pregant
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Posted: October 15, 2024
Watch Time: 45 minutes
Posted: April 25, 2025
Watch Time: 05:58 minutes
Hosted By:
By Dr. Barry Sears
Founder & President, Zone Labs
Mary Perry
Clinical Trials Director, Zone Labs
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Summary
Infertility is deeply personal—and increasingly common. In this episode of The Wellness Zone podcast, Dr. Barry Sears and Mary Perry explore the surprising connection between infertility and your metabolism.
What’s behind the rising rates of infertility in both women and men? According to Dr. Sears, it comes down to one key metabolic regulator: AMPK. From polycystic ovary syndrome (PCOS) to declining sperm count and motility, many root causes of infertility are tied to insulin resistance and low AMPK activity.
Dr. Sears explains:
Why obesity and insulin resistance impair fertility
How low AMPK affects sperm movement and egg viability
The role of metformin—and what it teaches us about boosting AMPK naturally
Why conception is a “metabolic symphony,” and what happens when it’s out of tune
If you’re struggling with infertility or simply curious about the science behind reproductive health, this episode provides a powerful and hopeful perspective grounded in the latest metabolic research.
Topics We Discuss:
[00:00]- Intro
[00:55]- Causes of Infertility. Body Fat makes it harder
[01:05]- Making ATP
[01:50]- Male Infertility and AMPK
[03:22]- Metformin and raising AMPK levels
[04:15]- Preparing to conceive by focusing on metabolism
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