What Really Causes Obesity? The Role of Metabolism, Insulin Resistance, and AMPK
Key Takeaways There is no doubt that obesity is on the rise. But why? Is it because we are not exercising enough? Or are we simply…
Read MoreAuthor: Barry Sears
Long COVID and Metabolism: How AMPK Activation May Reduce Risk
Key Takeaways It has been nearly five years since COVID-19 first appeared. However, for many, the consequences of initial infection remain with them for years. About…
Read MoreCan Epigenetic Clocks Predict Your Biological Age?
Key Takeaways Chronological Age vs Biological Age There are two types of age: chronological and biological. Chronological age is simple—it’s the date on your birthdate. Biological age…
Read MoreCalorie Restriction and Longevity: Why Metabolic Engineering® May Help You Live Longer
Key Takeaways Calorie restriction is the only proven way to extend lifespan. More importantly, it is also the best way to extend your healthspan, which is…
Read MoreDo GLP-1 Drugs Really Reduce Heart Attack Risk?
Key Takeaways Drug companies are far better marketers than developers of new medical breakthroughs. Terms like “revolutionary”, “game-changer”, or “medical breakthrough” are used as standard practice,…
Read MoreAllulose: The Sugar That May Help With Weight Loss and Metabolic Health
Key Takeaways Surprisingly, the answer is yes. The natural sugar allulose may help support weight loss because it activates AMPK and increases GLP-1, two metabolic signals…
Read MoreWhat Causes Leaky Gut? The Role of AMPK in Gut Barrier Health
Key Takeaways What Is Metabolic Endotoxemia? People are obsessed with gut health. They should be, because without a healthy gut, you would be a sitting target…
Read MoreGLP-1 Drugs for Weight Loss: Dr. Barry Sears Responds to JAMA Guidelines
Key Takeaways The Journal of the American Medical Association recently published an article on tips for using GLP-1 drugs (1). Are these tips valid? Let’s find…
Read MoreStopping GLP-1 Drugs: Why Weight Regain May Increase Heart Disease Risk
Key Takeaways Everyone wants to lose excess body fat. However, the Holy Grail of weight loss is losing excess body fat while maintaining, if not increasing,…
Read MoreHow Metabolic Engineering® Helps Reduce Chronic Inflammation
Key Takeaways Why Inflammation Is Both Necessary and Dangerous Inflammation is a crucial component of our metabolism that keeps us alive. It is our initial defense…
Read MoreWhat Sugar Really Does to Your Body: Glucose, Fructose, and Metabolic Health
A recent New York Times article examined how sugar affects the body. While the article covered some key points, it missed several important metabolic details. Key…
Read MoreHow to Measure Body Fat Percentage (And Why BMI Is Often Wrong)
Key Takeaways Excess body fat is strongly related to increased cardiovascular disease and mortality. The gold standard for measuring your percentage of body fat has always…
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