The goal of Metabolic Engineering® is to activate AMPK in the adipose tissue. Using the Zone diet component of Metabolic Engineering® to restrict calories without hunger or fatigue is the most powerful dietary approach for increasing AMPK activity. The omega-3 fatty acid dietary component of Metabolic Engineering® reduces neuroinflammation and promotes its resolution. 

The polyphenol dietary component of Metabolic Engineering® reduces oxidative stress. Equally important is that the omega-3 fatty acid and polyphenol components of Metabolic Engineering® are also indirect activators of AMPK activity. Thus, combining all three dietary interventions in Metabolic Engineering® provides the optimal dietary approach to maximizing AMPK activity to metabolize stored excess body fat for energy.