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  • 2025

Year: 2025

How Chronic Stress Causes Inflammation: The Role of AMPK

  • Barry Sears
  • Estimated read time 4 min read
  • December 2, 2025

Key Takeaways Over 75% of Americans report symptoms of stress. So, what exactly is stress biochemically, and more importantly, how can you reduce it?   Stress…

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Categories: Inflammation, Latest News, What Is AMPK?

What Causes AFib? The Role of Inflammation and AMPK

  • Barry Sears
  • Estimated read time 11 min read
  • December 2, 2025

Key Takeaways Atrial fibrillation (Afib) is the most common form of cardiac arrhythmia.  It is known that Afib is associated with an increased risk of stroke,…

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Categories: Heart Disease, Latest News

How Long Can Humans Fast? The Science of Fasting and Metabolism

  • Barry Sears
  • Estimated read time 5 min read
  • November 18, 2025

Key Takeaways The human body is surprisingly fragile. Most people can survive only about three minutes without oxygen and about three days without water. Beyond those…

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Categories: Ask Dr. Sears, Latest News

Omega-3 Fatty Acids Reduce Cardiovascular Death in Dialysis Patients

  • Barry Sears
  • Estimated read time 7 min read
  • November 18, 2025

Key Takeaways Can Omega-3 Fatty Acids Reduce Mortality in Dialysis Patients? Quick Answer Yes. A clinical study of more than 1,200 kidney dialysis patients found that…

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Categories: Kidney, Latest News

Alzheimer’s Disease and Insulin Resistance: Can Metabolic Engineering Help?

  • Barry Sears
  • Estimated read time 6 min read
  • October 31, 2025

Key Takeaways Effectively treating Alzheimer’s disease has been one of the most significant failures of the pharmacological industry.  Yet Alzheimer’s can be viewed as a metabolic…

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Categories: Alzheimers Disease, Latest News

What Is Obesity? BMI, Body Fat, and the New Medical Definition Explained

  • Barry Sears
  • Estimated read time 7 min read
  • October 29, 2025

Key Takeaways When the Supreme Court Justice Potter Stewart was asked how he defined hard-core pornography, he stated, “I know it when I see it”.  The…

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Categories: Latest News, Obesity

What Really Causes Obesity? The Role of Metabolism, Insulin Resistance, and AMPK

  • Barry Sears
  • Estimated read time 7 min read
  • September 23, 2025

Key Takeaways There is no doubt that obesity is on the rise.  But why?  Is it because we are not exercising enough? Or are we simply…

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Categories: Latest News, Obesity

Long COVID and Metabolism: How AMPK Activation May Reduce Risk

  • Barry Sears
  • Estimated read time 7 min read
  • September 23, 2025

Key Takeaways It has been nearly five years since COVID-19 first appeared.  However, for many, the consequences of initial infection remain with them for years.  About…

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Categories: Latest News, Metabolic Engineering®

Can Epigenetic Clocks Predict Your Biological Age?

  • Barry Sears
  • Estimated read time 6 min read
  • September 18, 2025

Key Takeaways Chronological Age vs Biological Age There are two types of age: chronological and biological.  Chronological age is simple—it’s the date on your birthdate. Biological age…

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Categories: aging, Healthspan, Latest News

Calorie Restriction and Longevity: Why Metabolic Engineering® May Help You Live Longer

  • Barry Sears
  • Estimated read time 7 min read
  • September 9, 2025

Key Takeaways Calorie restriction is the only proven way to extend lifespan.  More importantly, it is also the best way to extend your healthspan, which is…

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Categories: Latest News, Metabolic Engineering®, Stages of Life

Do GLP-1 Drugs Really Reduce Heart Attack Risk?

  • Barry Sears
  • Estimated read time 8 min read
  • September 3, 2025

Key Takeaways Drug companies are far better marketers than developers of new medical breakthroughs.  Terms like “revolutionary”, “game-changer”, or “medical breakthrough” are used as standard practice,…

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Categories: GLP-1 Drugs, Heart Disease, Latest News

Allulose: The Sugar That May Help With Weight Loss and Metabolic Health

  • Barry Sears
  • Estimated read time 5 min read
  • August 5, 2025

Key Takeaways Surprisingly, the answer is yes.  The natural sugar allulose may help support weight loss because it activates AMPK and increases GLP-1, two metabolic signals…

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Categories: diabetes, Latest News
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